ClamAV is the reigning free AV scanner, but there are commercial products for Linux too (read: very pricey).
One of them is offered by Sophos:
http://www.sophos.com/products/enterprise/endpoint/security-and-control/linux/
And of course, the big Windows players have their own linux suites too:
McAfee LinuxShield
and
Trend Micro ServerProtect for Linux, though you should be aware there is currently boycott in progress of Trend Micro products.
Symantec also supposedly has a linux solution, but I couldn't find it on their website anywhere.
At any rate, the product descriptions belie the unfortunate motive behind commercial AV software: to make lots and lots of money (actual protection of people's computers seems a lot of times to be a distant second priority). These solutions are intended for enterprise servers, run by businesses who don't want the embarrassment of passing on virus-infected content to people visiting their websites and downloading stuff. These companies see no money in offering a linux desktop-based AV solution, so they don't do it.
So, for a desktop or small hobby server, you're probably best off with ClamAV, running a firewall, and keeping on top of security updates.